Research Interests
His current research aims to delineate the role of exosomes-associated cargo bioactive molecules as a trojan horse in altering oncologic pathways in tumor and stromal cells to promote cancer progression and metastasis using tissue culture, preclinical model, and human specimens. The findings from his research are of great asset to have successfully competed for NIH support. The ultimate goal of his ongoing research is to utilize different therapeutic strategies for reducing drug resistance and improving the survival of patients with malignant diseases such as prostate cancer and melanoma. One of these strategies is to elucidate the underlying molecular mechanisms of aggressive phenotypes of tumors and discover specific and efficient therapeutic targets. In the same context, there is a critical need for the discovery of novel and reliable biomarkers that can stratify cancer patients according to their pathological stages, response to certain therapeutics, tumor relapse and other clinical outcomes.
Selected Publications
| Year | Faculty | Citation | PMID |
|---|---|---|---|
| 2022 | Zakaria Abd Elmageed | Al Omairi NE, Albrakati A, Alsharif KF, Almalki AS, Alsanie W, Abd Elmageed ZY, Zaafar D, Lokman MS, Bauomy AA, Belal SK, Abdel-Daim MM, Abdel Moneim AE, Alyami H, Kassab RB. Selenium Nanoparticles with Prodigiosin Rescue Hippocampal Damage Associated with Epileptic Seizures Induced by Pentylenetetrazole in Rats. Biology (Basel). 2022 Feb 23;11(3):354. PMID: 35336729. |
|
| 2022 | Zakaria Abd Elmageed | Ahmed EY, Abdelhafez OM, Zaafar D, Serry AM, Ahmed YH, El-Telbany RFA, Abd Elmageed ZY, Ali HI. Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives. Arch Pharm (Weinheim). 2022 Jun;355(6):e2100327. doi: 10.1002/ardp.202100327. Epub 2022 Mar 14. PMID: 35285986. |
|
| 2022 | Zakaria Abd Elmageed | Malkaram SA, Shatnawi A, Fan J, Carraway H, Denvir J, Primerano DA, Abd Elmageed ZY, Fandy TE. Differential Histone Posttranslational Modifications Induced by DNA Hypomethylating Agents. Cancer Control. 2022 Jan-Dec;29:10732748221074051. PMID: 35067084. |
|
| 2022 | Zakaria Abd Elmageed | Zerfaoui M, Toraih E, Ruiz E, Errami Y, Attia AS, Krzysztof M, Abd Elmageed ZY, Kandil E. Nuclear Localization of BRAFV600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells. Cancers (Basel). 2022 Jan 9;14(2):311.Ìý PMID: 35053476. Ìý |
|
| 2021 | Zakaria Abd Elmageed | Albrakati A, Alsharif KF, Al Omairi NE, Alsanie WF, Almalki ASA, Abd Elmageed ZY, Elshopakey GE, Lokman MS, Bauomy AA, Abdel Moneim AE, Kassab RB. Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities. Int J Nanomedicine. 2021 Dec 30;16:8447-8464. PMID: 35002238. |
|
| 2021 | Zakaria Abd Elmageed | Abdelwahed KS, Siddique AB, Qusa MH, King JA, Souid S, Abd Elmageed ZY, El Sayed KA. PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead. ACS Pharmacol Transl Sci. 2021 Oct 5;4(6):1771-1781. PMID: 34927009. |
|
| 2021 | Zakaria Abd Elmageed | Ali HEA, Gaballah MSA, Gaballa R, Mahgoub S, Hassan ZA, Toraih EA, Drake BF, Abd Elmageed ZY. Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men. Cancers (Basel). 2021 Oct 19;13(20):5236. PMID: 34680382. |
|
| 2021 | Zakaria Abd Elmageed | Zerfaoui M, Dokunmu TM, Toraih EA, Rezk BM, Abd Elmageed ZY, Kandil E. New Insights into the Link between Melanoma and Thyroid Cancer: Role of Nucleocytoplasmic Trafficking. Cells. 2021 Feb 10;10(2):367. PMID: 33578751. |
|
| 2021 | Zakaria Abd Elmageed | Makboul R, Abdelkawi IF, BadaryÌý DM , Hussein MRA, Rhim JS, Toraih EA , Zerfaoui M,Ìý Abd Elmageed ZY. Transmembrane and Tetratricopeptide Repeat Containing 4 Is a Novel Diagnostic Marker for Prostate Cancer with High Specificity and Sensitivity. Cells 2021, |
|
| 2020 | Zakaria Abd Elmageed | Elwaie TA, Abbas SE, Aly EI, George RF, Ali H, Kraiouchkine N, Abdelwahed KS, Fandy TE, El Sayed KA, Abd Elmageed ZY, Ali HI. HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability. J Med Chem. 2020 Dec 24;63(24):15906-15945. Epub 2020 Dec 14. PMID: 33314925. |
|
| 2020 | Zakaria Abd Elmageed | Gaballa R, Ali HEA, Mahmoud MO, Rhim JS, Ali HI, Salem HF, Saleem M, Kandeil MA, Ambs S, Abd Elmageed ZY. Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial - Mesenchymal Transition. Cancers (Basel). 2020 Aug 15;12(8):E2300. PMID: 32824235. |