Research Interests
My research interests include bioinformatics, genetics, genomics, computational biology, evolutionary biology, and cancer-related research. My research focuses on analyzing different kinds of genomic and transcriptomic data including those related to cancer and other diseases using the technologies of next-generation sequencing and third-generation sequencing (such as Oxford Nanopore), developing new tools/pipelines, and using comparative genomics tools to understand evolution and disease development in a systemic perspective. My capabilities are mostly computational and biostatistical.
Education
| 2017 | Virginia Polytechnic Institute and State University | PhD-Genetics, Bioinformatics and Computational Biology |
| 2010 | Xiamen University, Xiamen, China | MS-Computer Science |
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Selected Publications
| Year | Faculty | Citation | PMID |
|---|---|---|---|
| 2021 | Lin Kang, Pawel Michalak | Kang L, He G, Sharp AK, Wang X, Brown AM, Michalak P, Weger-Lucarelli J. A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation. ÌýCell. 2021 Aug 19;184(17):4392-4400.e4. PMID: 34289344. |
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| 2021 | Lin Kang, Ramu Anandakrishnan | Kinney N, Kang L, Bains H, Lawson E, Husain M, Husain K, Sandhu I, Shin Y, Carter JK, Anandakrishnan R, Michalak P, Garner H. Ethnically biased microsatellites contribute to differential gene expression and glutathione metabolism in Africans and Europeans. PLoS One. 2021 Mar 25;16(3):e0249148. doi: 10.1371/journal.pone.0249148. eCollection 2021. PMID: 33765058. |
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| 2020 | Pawel Michalak, Lin Kang | Gemmell NJ, Rutherford K, Prost S, Tollis M, Winter D, Macey JR, Adelson DL, Suh A, Bertozzi T, Grau JH, Organ C, Gardner PP, Muffato M, Patricio M, Billis K, Martin FJ, Flicek P, Petersen B, Kang L, Michalak P, Buckley TR, Wilson M, Cheng Y, Miller H, Schott RK, Jordan MD, Newcomb RD, Arroyo JI, Valenzuela N, Hore TA, Renart J, Peona V, Peart CR, Warmuth VM, Zeng L, Kortschak RD, Raison JM, Zapata VV, Wu Z, Santesmasses D, Mariotti M, Guigó R, Rupp SM, Twort VG, Dussex N, Taylor H, Abe H, Bond DM, Paterson JM, Mulcahy DG, Gonzalez VL, Barbieri CG, DeMeo DP, Pabinger S, Van Stijn T, Clarke S, Ryder O, Edwards SV, Salzberg SL, Anderson L, Nelson N, Stone C; Ngatiwai Trust Board. The tuatara genome reveals ancient features of amniote evolution. Nature. 2020 Aug;584(7821):403-409. PMID: 32760000. |
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| 2020 | Lin Kang | Budnick JA, Sheehan LM, Benton AH, Pitzer JE, Kang L, Michalak P, Roop RM 2nd, Caswell CC. Characterizing the transport and utilization of the neurotransmitter GABA in the bacterial pathogen (Brucella abortus). PLoS One. 2020 Aug 26;15(8):e0237371. PMID: 32845904. |
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| 2020 | Lin Kang | Pinzari CA, Kang L, Michalak P, Jermiin LS, Price DK, Bonaccorso FJ. Analysis of genotype sequence data reveals the origin and evolutionary separation of Hawaiian hoary bat populations. Genome Biol Evol. 2020 Aug 27:evaa137. PMID: 32853363. |
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| 2020 | Ramu Anandakrishnan, Tiffany Carpenetti, Lin Kang, Robin Varghese | Anandakrishnan R, Carpenetti TL, Samuel P, Wasko B, Johnson C, Smith C, Kim J, Michalak P, Kang L, Kinney N, Santo A, Anstrom J, Garner HR, Varghese RT. DNA sequencing of anatomy lab cadavers to provide hands-on precision medicine introduction to medical students. BMC Med Educ. 2020 Nov 16;20(1):437. PMID: 33198737. |
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| 2020 | Lin Kang | Budnik JA, Sheehan LM, Ginder M, Failor K, Perkowski J, Pinto J, Kohl K, Kang L, Michalak P, Luo L, Heindl J and Caswell C. A central role for the transcriptional regulator VtlR in small RNA-mediated gene regulation in Agrobacterium tumefaciens. Scientific Reports. 2020 Sep 11;10(1):14968. PMID: 32917931. |
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| 2020 | Lin Kang, Robin Varghese | Sheng KL, Kang L, Pridham KJ, Dunkenberger LE, Sheng Z, Varghese RT. An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. Sci Rep. 2020 Dec 4;10(1):21246. PMID: 33277589. |
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| 2019 | Lin Kang, Pawel Michalak, Ramu Anandakrishnan, Robin Varghese | Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR. CAGm: a Repository of Germline Microsatellite Variations in the 1000 Genomes Project, Nucleic Acids Res. 2019 Jan 8;47(D1):D39-D45. PMID: 30329086. |
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| 2019 | Lin Kang, Pawel Michalak, James Mahaney | Kang L, Rashkovetsky E, Michalak K, Garner HR, Mahaney JE, Rzigalinski BA, Korol A, Nevo E, Michalak P. Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11839-11844. PMID: 31127048. |
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| 2019 | Lin Kang, Ramu Anandakrishnan, Robin Varghese | Kinney N, Kang L, Eckstrand L, Pulenthiran A, Samuel P, Anandakrishnan R, Varghese RT, Michalak P, Garner HR. Abundance of ethnically biased microsatellites in human gene regions. PLoS One. 2019 Dec 12;14(12):e0225216. PMID: 31830051. |
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| 2019 | Lin Kang | Van Hoek ML, Prickett MD, Settlage RE, Kang L, Michalak P, Vliet KA, Bishop B. The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters. BMC Genomics. 2019 Aug 30;20(1):684. PMID: 31470795. |
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| 2019 | Lin Kang | Lang JJ, Snyder RJ, Clapsadl MD, Michalak P, Kang L, Pérez-Fuentetaja A. Morphometric differentiation and gene flow in emerald shiners (Notropis atherinoides) from the lower Great Lakes and the Niagara River. Journal of Great Lakes Research. 2019 Apr;45(2):324-332. DOI: 10.1016/j.jglr.2018.12.002. |
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| 2018 | Lin Kang | Michalak P, Kang L. Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals. Hereditas. 2018 Nov 3;155:34. PMID: 30410429. |
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| 2018 | Lin Kang | Chen YT, Chang IY, Liu H, Ma CP, Kuo YP, Shih CT, Shih YH, Kang L, Tan BC. Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem. 2018 Jun 29;293(26):10158-10171. PMID: 29769310. |
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| 2018 | Lin Kang | Budnick JA, Sheehan LM, Kang L, Michalak P, Caswell CC. Characterization of three small proteins in Brucella abortus linked to fucose utilization. J Bacteriol. 2018 Aug 24;200(18). pii: e00127-8. PMID: 29967118. |
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| 2018 | Lin Kang | Velmurugan KR, Michalak P, Kang L, Fonville NC, Garner HR. Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia. Mol Genet Genomic Med. 2018 Nov;6(6):1199-1208. PMID: 30450770. |
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| 2018 | Lin Kang | Michalak P, Kang L, Schou MF, Garner HR, Loeschcke V. Genomic signatures of experimental adaptive radiation in Drosophila. Mol Ecol. 2019 Feb;28(3):600-614. PMID: 30375065. |
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| 2017 | Lin Kang | Kang L, George P, Price DK, Sharakhov I, Michalak P. Mapping Genomic Scaffolds to Chromosomes Using Laser Capture Microdissection in Application to Hawaiian Picture-Winged Drosophila. Cytogenet Genome Res. 2017;152(4):204-212. PMID: 29130948. |
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| 2017 | Lin Kang | Michalak P, Kang L, Ciparis S, Henley W, Jones J, Phipps A, Hallerman E. Freshwater mussels exposed to arsenic and sulfate show contrasting patterns of gene expression. In Organismal and Molecular Malacology (Ed. S. Ray). 2017 Aug 16:99-117. DOI: 10.5772/67674. |
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| 2017 | Lin Kang, Pawel Michalak | Yablonovitch AL, Fu J, Li K, Mahato S, Kang L, Rashkovetsky E, Korol AB, Tang H, Michalak P, Zelhof AC, Nevo E, Li JB. Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates. Nat Commun. 2017 Nov 17;8(1):1570. PMID: 29146998. |
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| 2014 | Katarzyna Michalak, Lin Kang, Pawel Michalak | Kim YB, Oh JH, McIver LJ, Rashkovetsky E, Michalak K, Garner HR, Kang L, Nevo E, Korol AB, Michalak P. Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10630-5. PMID: 25006263. |