Education
| 2018 | Edward Via College of Osteopathic Medicine | Postdoc |
| 2017 | Virginia Tech Carilion Research Institute | Postdoc |
| 2016 | Virginia Polytechnic Institute and State University | PhD-Genetics, Bioformatics, and Computational Biology |
| 2006 | Texas A&M University, Corpus Christi | BS-Biology |
Research Interests
My research interests include: 1) identification of molecular biomarkers predicative of cancer progression 2) biomarker and drug target discovery in polygenic disorders e.g. atrial fibrillation, glioblastoma, non-small cell lung cancer 3.) medical education in the field of genetics, research design, and introducing medical students to the benefits and limitations of precision medicine.
My research capabilities include: genomics, molecular biology, cell biology, and bioinformatics.
My lab’s focus is to discover gene signatures involved in cancer progression and in the predisposition of certain polygenic diseases. Our goal is to utilize these novel biomarkers to identify new therapeutic targets and develop prognostic assays which can be implemented in the clinic.
Awards
- Virginia Polytechnic Institute and State University, NSF S STEM Award, 2013-2014
Selected Publications
| Year | Faculty | Citation | PMID |
|---|---|---|---|
| 2022 | Robin Varghese | Pridham KJ, Shah F, Hutchings KR, Sheng KL, Guo S, Liu M, Kanabur P, Lamouille S, Lewis G, Morales M, Jourdan J, Grek CL, Ghatnekar GG, Varghese R, Kelly DF, Gourdie RG, Sheng Z. Connexin 43 confers chemoresistance through activating PI3K. Oncogenesis. 2022 Jan 12;11(1):2. doi: 10.1038/s41389-022-00378-7. PMID: 35022385. |
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| 2020 | Ramu Anandakrishnan, Tiffany Carpenetti, Lin Kang, Robin Varghese | Anandakrishnan R, Carpenetti TL, Samuel P, Wasko B, Johnson C, Smith C, Kim J, Michalak P, Kang L, Kinney N, Santo A, Anstrom J, Garner HR, Varghese RT. DNA sequencing of anatomy lab cadavers to provide hands-on precision medicine introduction to medical students. BMC Med Educ. 2020 Nov 16;20(1):437. PMID: 33198737. |
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| 2020 | Lin Kang, Robin Varghese | Sheng KL, Kang L, Pridham KJ, Dunkenberger LE, Sheng Z, Varghese RT. An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. Sci Rep. 2020 Dec 4;10(1):21246. PMID: 33277589. |
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| 2019 | Robin Varghese | Sheng KL, Pridham KJ, Sheng Z, Lamouille S, Varghese RT. Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability. Frontiers in Oncology. 2019 Jan 8;8:662. PMID: 30671385. |
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| 2019 | Lin Kang, Pawel Michalak, Ramu Anandakrishnan, Robin Varghese | Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR. CAGm: a Repository of Germline Microsatellite Variations in the 1000 Genomes Project, Nucleic Acids Res. 2019 Jan 8;47(D1):D39-D45. PMID: 30329086. |
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| 2019 | Ramu Anandakrishnan, Robin Varghese | Dash S, Kinney N, Varghese R, Garner H, Feng W, Anandakrishnan R. Differentiating between cancer and normal tissue samples using multi-hit combinations of genetic mutations. Sci Rep. 2019 Jan 30;9(1):1005. PMID: 30700767. |
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| 2019 | Ramu Anandakrishnan, Robin Varghese | Anandakrishnan R, Varghese R, Kinney N, Garner HR. Estimating the number of genetic mutations (hits) required for tumorigenesis based on the distribution of somatic mutations. PLoS Comput Biol. 2019 Mar 7;15(3):e1006881. PMID: 30845172. |
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| 2019 | Lin Kang, Ramu Anandakrishnan, Robin Varghese | Kinney N, Kang L, Eckstrand L, Pulenthiran A, Samuel P, Anandakrishnan R, Varghese RT, Michalak P, Garner HR. Abundance of ethnically biased microsatellites in human gene regions. PLoS One. 2019 Dec 12;14(12):e0225216. PMID: 31830051. |
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| 2018 | Robin Varghese | Varghese RT, Young S, Pham L, Liang Y, Pridham KJ, Guo S, Murphy S, Kelly DF, Sheng Z. Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival. Scientific Reports. 2018 Sep 11;8(1):13621. PMID: 30206363. |
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| 2018 | Robin Varghese | Kinney N, Larsen TR, Kim DM, Varghese RT, Poelzing S, Garner HR, AlMahameed ST. Whole Exome Sequencing Reveals Microsatellites DNA Markers for Response to Dofetilide Initiation in Patients with Persistent Atrial Fibrillation, A Pilot Study. Clin Cardiol. 2018 Apr 19. PMID: 29671888. |
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| 2017 | Robin Varghese | Pridham, KJ, Varghese RT, Sheng Z. The Role of Class IA PI3K Catalytic Subunits in Glioblastoma. Frontiers in Oncology. 2017 Dec 15. |
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| 2017 | Ramu Anandakrishnan, Robin Varghese | Kinney N, Varghese RT, Anandakrishnan R, Garner HR. ZDHHC3 as a risk and mortality marker for breast cancer in African American Women. Cancer Informatics. 2017;16:1–6. PMID: 29276372. |
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| 2017 | Robin Varghese | Velmurugan KR, Varghese RT, Fonville NC, Garner HR. High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification. Oncogene. 2017 Jul 31. Epub ahead of print. PMID: 28759038. |